10 Biggest Biotechnology Companies


The biotechnology industry, a fusion of biology and technology, plays a crucial role in developing innovative treatments for various diseases and medical conditions. This dynamic industry encompasses a wide range of applications, including pharmaceuticals, medical devices, biofuels, and biomaterials. Among the giants in this field are companies like Novo Nordisk and Moderna, which have made significant strides in creating new drug compounds and medical solutions. 

The path to success in biotechnology often involves extensive research, trials, and approval processes, posing unique challenges and opportunities for investors. This article delves into the top ten biotechnology companies, as measured by their 12-month trailing revenue, highlighting their contributions to medical and technological advancements and their impact on the global healthcare landscape.

#1 Novo Nordisk A/S (NVO)

Novo Nordisk, a leader in the biotech industry with $24.31 billion in TTM revenue, is renowned for its focus on diabetes care, hemophilia care, growth hormone therapy, and hormone replacement therapy. The Denmark-based company’s diverse drug portfolio, including well-known brands like Levemir and Victoza, underscores its commitment to enhancing patient care.

#2 Moderna Inc. (MRNA)

Moderna, incorporated in 2010 and based in Cambridge, MA, has a TTM revenue of $20.68 billion. The company gained prominence for its mRNA-based COVID-19 vaccine and focuses on treating autoimmune disorders, rare and infectious diseases, and immuno-oncology, showcasing its innovative approach to medicine.

#3 BioNTech SE (BNTX)

BioNTech, with a TTM revenue of $20.37 billion, is based in Mainz, Germany. Founded by Ugur Sahin and Ozlem Turci, the company gained fame for its partnership with Pfizer in developing a COVID-19 vaccine and is dedicated to tailoring cancer treatments for individual patients.

#4 Regeneron Pharmaceuticals Inc. (REGN)

Regeneron Pharmaceuticals, generating $13.71 billion in TTM revenue, develops treatments for eye disease, cancer, cardiovascular diseases, and more. The company’s large-scale gene sequencing operations through its Regeneron Genetics Center highlight its commitment to cutting-edge research.

#5 Vertex Pharmaceuticals Inc. (VRTX)

Vertex Pharmaceuticals, with $8.7 billion in TTM revenue, focuses on drug treatments for cancer, cystic fibrosis, autoimmune diseases, and neurological disorders. Its dedication to creating innovative therapies has made it a significant player in the biopharmaceutical sector.

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#6 Jazz Pharmaceuticals PLC (JAZZ)

Jazz Pharmaceuticals, an Irish biopharmaceutical company with a TTM revenue of $3.58 billion, specializes in addressing narcolepsy, psychiatry, pain management, and oncology, demonstrating its diverse therapeutic focus.

#7 Incyte Corp. (INCY)

Incyte, primarily focusing on small molecule drugs for oncology, boasts a TTM revenue of $3.33 billion. Known for its drug Jakafi, a treatment for myelofibrosis, Incyte has established itself as a leader in developing and marketing innovative therapies.

#8 Novavax, Inc. (NVAX)

Novavax, headquartered in Gaithersburg, MD, with a TTM revenue of $2.39 billion, specializes in developing vaccines for infectious diseases. The company’s commitment to global vaccine access and disease prevention underlines its significant role in public health.

#9 Vir Biotech Inc. (VIR)

Vir Biotech, with a TTM revenue of $2.37 billion, focuses on treatments for infectious diseases. The company has developed a COVID-19 treatment, Sotrovimab, and continues to advance its pipeline of therapies, emphasizing its role in combating global health crises.

#10 BioMarin Pharmaceutical Inc. (BRMN)

BioMarin Pharmaceutical, with a TTM revenue of $2.01 billion, develops treatments for genetic disorders like phenylketonuria and achondroplasia. Founded in 1997, BioMarin’s commitment to addressing rare genetic diseases has made it a key player in biotech.


Biotechnology companies, as highlighted in this list, play a transformative role in enhancing biological studies and developments, significantly impacting how we live and treat our planet. These top companies, from Novo Nordisk to BioMarin, are at the forefront of using technology to create groundbreaking medicines, vaccines, and other products that improve our health and well-being. The biotech industry, characterized by its focus on specific conditions like cancer and infectious diseases, continues to push the boundaries of scientific discovery. 

Despite the challenges of lengthy trial and approval processes, these companies have risen to prominence, underscoring the industry’s potential for continued growth and innovation. As they navigate the complexities of biotechnology, these enterprises not only contribute to the global healthcare system but also pave the way for future advancements that will further enrich human life and the environment.